舒红兵院士连发两篇JBC病毒先天免疫应答负反馈调控最新进展
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发布时间：2024-05-15
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舒红兵院士连发两篇JBC病毒先天免疫应答负反馈调控最新进展
关于傲锐东源（OriGene）公司OriGene自1996年以来一直致力于研发TrueClone，它拥有用于基因功能研究的最大全长cDNA克隆库。OriGene的旗舰产品是TrueClone库，可检索的资源有超过33,000个适合转染和蛋白表达的人类全长cDNA克隆和超过25,000个带有人ORF克隆标签的TrueORF克隆。OriGene以全面的cDNA克隆为基础，开发了多个独特的科学研究工具，包括提供多达8,000种人重组蛋白和6,000种人源全长抗原制备的TrueMAB单克隆抗体。欢迎登陆OriGene公司网站了解更多信息：http://www.origene.com/北京傲锐东源生物科技有限公司联系电话：400-6744363/ 800-9904363武汉大学生科院舒红兵教授2011年当选中科院院士，主要从事免疫相关的细胞信号传导研究，在抗病毒天然免疫反应等领域取得了一系列有重要国际影响的成果。近期其研究组接连在JBC杂志上发表文章，“FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3”这篇文章中，研究人员确认了转录因子FoxO1在病毒诱发IFN-β过程中发挥负反馈调节作用，揭示出转录因子FoxO1在病毒诱发IFN-β过程中发挥负反馈调节作用，从而提供了一条控制I型IFN诱导和细胞抗病毒应答的新机制FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3Received for publication, December 12, 2012, andinrevised form, March8,2013 Published, JBC Papers in Press,March26,2013, DOI10.1074/jbc.M112.444794Cao-Qi Lei, Yu Zhang, Tian Xia, Li-Qun Jiang, Bo Zhong, and Hong-Bing Shu1From the State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaAbstractViral infection causes activation of the transcription factor IRF3, which is critical for production oftype I interferons (IFNs) and innate antiviral immune response.How virus-induced type I IFN signaling iscontrolled is not fully understood.Here we identified the transcription factor FoxO1 as a negative regulatorfor virus-triggered IFN-β induction. Overexpression of FoxO1 inhibited virus-triggered ISRE activation, IFN-β induction as well as cellular antiviral response, whereas knockdown of FoxO1 had opposite effects.FoxO1 interacted with IRF3 in a viral infection-dependent manner and promoted K48-linked polyubiquitination and degradation of IRF3 in the cytosol.Furthermore, FoxO1-mediated degradation of IRF3 was independentof the known E3 ubiquitin ligases for IRF3, including RBCK1 and RAUL.Our findings thus suggest that FoxO1 negatively regulates cellular antiviral response by promoting IRF3ubiquitination and degradation, providing a previously unknown mechanism for control of type I IFN inductionand cellular antiviral respons在这一研究中，Origene提供的CelPainterTMl是一个至关重要的研究工具。这一研究成果充分的证明了Origene提供的便于观察亚细胞结构的荧光蛋白标记的TrueORF克隆的可靠性CellPainterTM 细胞器标记物的应用标记细胞器，无需抗体或化学物质。蛋白示踪。细胞器形态学和动力学研究。蛋白和细胞器的结合位点研究。富集或纯化过程中的成分示踪。本文链接： http://origen.immuno-online.com/view-1375863666.html
